Sister mary joseph nodule differential diagnosis

We therefore suggest that pancreatic cancer should be included in the differential diagnosis when an. Segovis CM1 Dyer RB2.

Its association with intra abdominal desmoplastic small round cell tumour is extremely rare.

Sister mary joseph nodule differential diagnosis. Sister Mary Josephs nodule SMJN represents an unusual clinical feature of metastatic deposit at the umbilicus originating from an intra-abdominal malignancy. To outline the paucity of such a condition review the associated pathologies and demonstrate the importance of clinical and histopathologic correlation. Sister Mary Josephs nodule SMJN refers to a metastatic tumor of the umbilicus.

It is a rare entity which arises from a malignancy in the intra-abdominal cavity. We herein describe a patient who presented with SMJN as his first sign of pancreatic cancer. It is an even more unusual case of SMJN.

We therefore suggest that pancreatic cancer should be included in the differential diagnosis when an. A Sister Mary Joseph nodule is an umbilical metastasis of an internal malignancy. In the largest series reported the most common primary malignancies were stomach 20 large bowel 14 ovary 14 and pancreas 11.

In 20 of cases the primary could not be established. In 14 of cases a Sister Mary Joseph nodule was the initial presentation of the internal malignancy. Sister Mary Josephs nodule is an important physical sign.

It usually represents umbilical metastasis of intra abdominal malignancy. Its association with intra abdominal desmoplastic small round cell tumour is extremely rare. We describe a rare case of sister Mary Josephs nodule associated with desmoplastic small round cell tumour.

We conclude that differential diagnosis of Sister. The Sister Mary Joseph Nodule. Segovis CM1 Dyer RB2.

1Department of Radiology Wake Forest Baptist Medical Center Wake Forest University School of Medicine Medical Center Blvd Winston-Salem NC 27157 USA. Clinical differential diagnosis at that time included a pyogenic granuloma versus a Sister Mary Joseph nodule SMJN. A shave biopsy was performed.

Histopathology revealed multiple cystic and duc-tal spaces lined by atypical epithelial cells with numerous mitotic figures in the dermis Figures 2 and 3. These changes favored a gastrointestinal. A malignant umbilical mass can represent a primary or metastatic lesion.

The term Sister Mary Josephs nodule was first used by Sir Hamilton Bailey in 1949 1 in order to describe the entity of metastatic umbilical lesions. We present three cases of Sister Mary Josephs nodule. Sister Josephs nodule is a lymphatic metastasis to the umbilical region.

The differential diagnosis of an umbilical nodule includes but is not limited to granuloma pyogenic foreign body. The Sister Mary Joseph nodule is a manifestation of umbilical metastasis of malignancy typically arising from the gastrointestinal or genitourinary tract. Sister Mary Josephs nodule is an eponymous term referring to a malignant metastatic umbilical nodule.

It is a rare but important physical finding as it is a sign of advanced stage of malignancy. This case report describes an 82-year-old female diagnosed with metastatic pancreatic adenocarcinoma presenting with a Sister Mary Josephs nodule. This is an unusual presentation of pancreatic malignancy.

In fact the patients umbilical ulcer is a classic presentation of a Sister Mary Josephs SMJ nodule. 2 An SMJ nodule is defined as an umbilical metastasis of an underlying intra-abdominal. The diagnosis of Sister Mary Josephs nodule is usually delayed due to non-specific symptoms that are often misinterpreted as benign umbilical nodules.

The lack of suspicion and general reluctance to perform invasive investigations contributes to late diagnosis. Sister Mary Josephs nodule is usually located several centimeters away from the possible omental disease. It can be seen or felt deep in the subcutis in the umbilical area.

Incidental detection of such a metastasis for umbilical hernia repair is also described 10. In cases of diagnostic uncertainty or inconclusive initial investigations diagnostic laparoscopy has a high diagnostic yield and should be considered in the diagnostic workup. A Sister Mary Joseph nodule is an eponymous sign referring to a palpable umbilical nodule caused by metastases from an abdominal or pelvic malignancy.

Abdominal tuberculosis can present with a similar benign pseudo.