Neuroendocrine tumor metastases to bone prognosis

Men had more bone metastases compared to women. Their presence carries along a poor prognosis.

NETs show a clear preference to metastasize to the liver.

Neuroendocrine tumor metastases to bone prognosis. Bone metastases arising from neuroendocrine tumors are a well-recognized complication. Their presence carries along a poor prognosis. Clinical symptoms are similar to those encountered in other forms of cancer that are complicated by bone metastasis.

Over the last decade or so the clinical detection diagnostic methods and treatment strategies have changed dramatically and new. Bone metastases arising from neuroendocrine tumors are a well-recognized complication. Their presence carries along a poor prognosis.

Clinical symptoms are similar to those encountered in other. Bone represents a common site of metastases for several solid tumors. However the ability of neuroendocrine neoplasms NENs to localize to bone has always been considered a rare and late event.

Thanks to the improvement of therapeutic options which results in longer survival and of imaging techniques particularly after the introduction of positron emission tomography PET with gallium peptides the diagnosis. Bone metastases arising from neuroendocrine tumors are a well-recognized complication. Their presence carries along a poor prognosis.

Clinical symptoms are similar to those encountered in other forms of cancer that are complicated by bone metastasis. Over the last decade or so the clinical detection diagnostic methods and. The risk of metastasis was highest if the primary was in the small intestine or pancreatohepatobiliary tract whereas it was lower with appendiceal and rectal NET.

Men had more bone metastases compared to women. Patients with metastatic NET had worse prognosis if the primary site was unknown 11 months 9 of NET patients compared to those whose primary was known 19 months. Metastatic neuroendocrine cancer prognosis - The neuroendocrine tumor is a rare tumor that presents complex problems for diagnosis and treatment.

Even in the case of metastatic spread to the liver there are some important differences in the nature of these tumors in comparison with gastrointestinal and pancreatic cancer. They usually show specific clinical symptoms and signs and. If you have a neuroendocrine tumour NET you may have questions about your prognosis.

A prognosis is the doctors best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. Only a doctor familiar with your medical history the type stage and characteristics of the cancer the treatments chosen and the response to treatment can put.

Three cases of metabolic bone disease in the setting of metastatic neuroendocrine tumor NET are illustrated with associated etiopathologies. One of these cases harbored mixed lesions in the form of vertebral metastasis biopsy proven while the other skeletal lesions were caused due to metabolic bone disease related to multiple parathyroid adenomas. While the metastatic lesion was positive on 68Ga.

If a neuroendocrine tumour NET spreads it can spread to the following. Tissues or structures near the organ where the cancer started such as the peritoneum the pleura or fat tissue. Lymph nodes around where the cancer started regional lymph nodes liver.

Brain metastases BM are rarely reported in patients with neuroendocrine carcinoma NEC of non-lung origin and neuroendocrine tumors NET of the gastroenteropancreatic GEP or bronchopulmonary system. However symptomatic brain metastases are associated with dismal prognosis so early detection and treatment could be advisable. We retrospectively analyzed 51.

Men had more bone metastases compared to women. Patients with metastatic NET had worse prognosis if the primary site was unknown 11 months 9 of NET patients compared to those whose primary was known 19 months. The metastatic potential of NETs varies profoundly depending on the primary site.

NETs show a clear preference to metastasize to the liver. Surveillance of liver metastases may enable earlier diagnosis and treatment. Neuroendocrine tumors NETs are neoplasms that arise from cells of the endocrine and nervous systemsThey most commonly occur in the intestine where they are often called carcinoid tumors but they are also found in the pancreas lung and the rest of the body.

Although there are many kinds of NETs they are treated as a group of tissue because the cells of these neoplasms share common. Men had more bone metastases compared to women. Patients with metastatic NET had worse prognosis if the primary site was unknown 11 months 9 of NET patients compared to those whose primary was known 19 months.

The metastatic potential of NETs varies profoundly depending on the primary site. NETs show a clear preference to metastasize to the liver. Neuroendocrine tumors typically arise from pancreatic PNET vs.

Gastrointestinal or thoracic origins non-PNET. The impact of primary tumor site on long-term prognosis following resection of neuroendocrine liver metastasis NELM remains poorly defined. The objective of the current study was to define the association of primary tumor location on prognosis of patients.

Pancreatic neuroendocrine tumors NETs are rare neoplasms that develop from the endocrine tissues of the pancreas. They have a better overall prognosis than pancreatic adenocarcinoma. However all commonly used classification systems reflect a separation between more indolent well-differentiated tumors and far more aggressive poorly differentiated types that behave clinically more like small-cell.

Bone metastases are reported in 10 to 12 of patients with neuroendocrine neoplasms NENs and can lead to pain and skeletal-related events SREs resulting in. On abdominal CT a generalised neoplastic process with metastases in the liver pancreas adrenal glands lymph nodes bones thoracic wall and a suspected metastasis in the right breast was revealed. Histopathology of the skin nodules confirmed a neuroendocrine tumour.

Metastases of a pancreatic neuroendocrine tumour or small-cell lung cancer were suspected on immunohistochemistry. The patient died before we were able to localise the primary source of the tumour. Bone metastases are clinically detected in a low per- centage of patients with advanced NET tumors.

Characteristic symptoms for bone metastases are. 1 pain principal symptom which can be accompanied by 2 pathological fractures andor 3 symptoms from hy- percalcemia 3 4.