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Interacts with lncRNAs such as. MicroRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.
Found in the human reference genome.
Hsa let 7a 5p. MISSION microRNA Mimic hsa-let-7a. Find Sigma-Aldrich-HMI0005 MSDS related peer-reviewed papers technical documents similar products more at Sigma-Aldrich. Homo sapiens human hsa-let-7a-5p sequence is a product of MIRLET7A2 let-7a-5p let-7a MIRLET7A1 hsa-let-7a let-7 MIRLET7A3 hsa-let-7a-5p genes.
Found in the human reference genome. Interacts with lncRNAs such as. Let-7a-5p is a microRNA which inhibits migration invasion as well as epithelial-mesenchymal transition by targeting several oncogenes.
Moreover cell proliferation colony formation migration and invasion were decreased after induced overexpression of let-7a in breast cancer cells. Used to sense miRNA activity using fluorescence based tools. Hsa-let-7a-5p target in 3 UTR of of mKate.
MiRNA activity can be measured by the repression of mKate2 relative to EBFP2 fluorescent proteins. TOOL miRNA RT-qPCR primerprobe set is an integral part of TOOL miRNA RT-qPCR assay which is based on two-step RT-qPCR to especially target microRNAs. Each TOOLS miRNA RT-qPCR primerprobe set is packaged including two parts.
One tube containing the unique designed stem-loop RT primer and the other containing a mix of the qPCR probe. Similar to following miRCarta miRNAs. Sequence 5 - 3 22 nts UGAGGUAGUAGGUUGUAUAGUU.
Hsa-let-7a-3 MI0000062 chr2246112752-46112773 Located in precursor. Hsa-let-7a-2 MI0000061 chr11122146568-122146589 - Located in precursor. Mature sequence hsa-let-7a-5p Accession.
Mature sequence hsa-let-7a-5p Accession number. Hsa_circ_0005519 was upregulated and negatively correlated with hsalet7a5p expression in CD4 T cells of asthmatic patients. Both the fraction of exhaled nitric oxide FeNO and the peripheral blood eosinophil ratio were positively correlated with hsa_circ_0005519 expression in CD4.
Here you can find additional information about hsa-let-7a-5p. Network representation of miRNA and target genes. In this table all targets of hsa-let-7a-5p are shown for the different evidence sets.
6mer count 6mer position 7mer-A1 count 7mer-A1 position 7mer-m8 count 7mer-m8 position 8mer count 8mer position NM_000016. 2410 877 807 566 –1. 2003 1854 1807 1499 689 –1.
Let-7a-5p represses proliferation migration invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells. Inhibition effect of exosomes-mediated Let-7a on the development and metastasis of triple negative breast cancer by. Hsa-let-7a-5p Description From NCBI Gene.
MicroRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. MiRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts pri-miRNAs that can be either protein-coding. Enter one or more mirBase names separated by spaces or commas.
Hsa-let-7-5p mmu-miR-299 Enter the Genbank accession number s or gene symbols s of the target s Enter one or more accession numbers or gene IDs separated by spaces or commas. NM_000024 NM_000021 NM_000017 LIN54. MiRTargetLink found 685 genes that are targeted by hsa-let-7a-5p.
45 interactions with strong support. 549 interactions with weak support. MISSION Synthetic microRNA Inhibitor Human hsa-let-7a-5p.
Find Sigma-Aldrich-HSTUD0001 MSDS related peer-reviewed papers technical documents similar products more at Sigma-Aldrich. The RDM0023H hsa-miR-let-7a-5p miREIA is an enzyme immunoassay for the quantitative measurement of human microRNA-let-7a-5p. FEATURES It is intended for research use only The total assay time is less than 25 hours The kit measures hsa -miR let 7a 5p isolated from human blood and cell culture lysates Assay format is 96 wells.