Ga 68 dotatate protocol

1 bottle of Redicat to consume after injection of Ga-68 DOTATATE. Measured human dosimetry of the 68 Ga-labeled synthetic somatostatin analog 68 Ga-DOTATATE has not been reported in the peer-reviewed literature.

68Ga has a short half-life of 68 minutes compared with 28 days for 111In resulting in a lower radiation dose to the pa-tient with an effective dose of.

Ga 68 dotatate protocol. Routine protocol is water oral contrast during the uptake phase and for 1 hour prior when possible If positive oral contrast is requested by the radiologist. 1 bottle of Redicat to consume after injection of Ga-68 DOTATATE. 68Ga-Dotatate PET-CT Scanning Protocol UK 1.

Introduction This protocol MUST be used when performing 68-Ga Dotatate PET-CT imaging. Scope The procedures laid out in this protocol apply to the radiographer technologists in PET-CT and should be carried out when performing a 68-Ga Dotatate PET-CT. Gallium-68 radiolabeled-DOTATATE imaging which is a sensitive method of detecting staging characterizing the disease and monitoring the effects of therapy 2.

Gallium-68 DOTATATE PETCT is proven to have high impact on the management of neuroendocrine patients compared to traditional anatomical imaging. Gallium-68 DOTATATE imaging also provides additional. Ga-68 NETSPOT Ga-68 dotatate Overview Ga-68 dotatate binds to somatostatin receptors with highest affinity for subtype 2 receptors sstr2.

It binds to cells that express somatostatin receptors including malignant cells which overexpress sstr2 receptors. Gallium 68 68Ga is. Dit protocol gegevens de radiolabeling van 68 Ga-DOTATATE kwaliteitscontrole patiënt voorbereiding en latere PETCT beeldvorming.

Veiligheid van de straling en beperkingen van de tijd als gevolg van de korte halfwaardetijd van 68 Ga worden in aanmerking genomen. Must have presence of SSTR disease as documented by positive Ga-68-DOTATATE PET scan within 12 weeks of anticipated treatment. -Positivity of Ga-68-DOTATATE PET scan defined as having at least one lesion that is greater than or equal to 10 mm in diameter with uptake that is higher than or equal to liver and is qualitatively higher and distinguishable from background activity.

68Ga is a generator-produced positron emitter that allows on-site on-demand availability. It should not be confused with 67Ga which is a single photon emitter. 68Ga has a short half-life of 68 minutes compared with 28 days for 111In resulting in a lower radiation dose to the pa-tient with an effective dose of.

Measured human dosimetry of the 68 Ga-labeled synthetic somatostatin analog 68 Ga-DOTATATE has not been reported in the peer-reviewed literature. 68 Ga-DOTATATE is an investigational PETCT imaging agent that binds with high affinity to somatostatin receptor subtype 2 found on many human cancers most classically neuroendocrine tumors but also others. 68Ga-PSMA PET-CT Scanning Protocol UK 1.

Introduction This protocol MUST be used when performing 68-Gallium 68-Ga Prostate Specific Membrane Antigen PSMA PET-CT imaging. Scope The procedures laid out in this protocol apply to the radiographer technologists in PET-CT and MUST be carried out when performing a 68-Ga PSMA PET-CT. The follow-up protocol at the University of Munich in addition to standard imaging modalities includes routine 68 Ga-DOTATATE PETCT examinations every 312 months in gastroenteropancreatic NETs with grading G1 or G2 and in some circumstances in lung NETs as well typical or atypical carcinoid tumors depending on the recurrence probability and primary.

68Ga-DOTATATE PETCT identified more lesions than other imaging modalities. With the results of the present study and the increasing availability and use of DOTA analogs in the therapy of neuroendocrine tumors we expect that 68Ga-DOTATATE PETCT will become the preferred functional imaging mod. 68Ga-DOTATATE will be injected into a vein in your arm then scans pictures are taken using the PET scans.

These pictures will allow the doctor to see the inside of your body. 68Ga-DOTATATE has been approved by the FDA Food and Drug Administration for PETCT imaging of patients with somatostatin receptor positive neuroendocrine tumors. Preferably with Ga-68 DOTATATE but In-111 Octreoscan is acceptable.

Authorized User will verify the positive findings with reviewing the scans in PACS or HealthLink. Patient has no untreated or non-stable brain metastases. Radiation Safety will contact patient to conduct Radiation Safety training and identify areas of radiation safety concern.

Ga-68 DOTATATE has been approved by the FDA on 612016 as a PETCT probe. 3 Ga-68 DOTATATE targets mainly somatostatin receptor subtype 2 SSTR2 and provides superior image quality lower radiation dosimetry and greater patient convenience compared to In-111 octreotide. 68Ga- DOTATATE prepa-ration and quality control is performed according to a standard protocol as described elsewhere26 Images are acquired approximately 45 min after intravenous bolus injection of 100 MBq 68Ga-ATATE with 253 min DOT per bed position.

A low-dose CT scan is acquired for attenuation correction and anatomical correlation. Ga 68 dotatate solution can be used up to 4 hours after reconstitution. The recommended activity to be administered for PET imaging in adults is 2 MBqkg.

After reconstitution and radiolabeling handle the Ga 68 dotatate injection with appropriate safety measures to minimize radiation exposure see. Warnings and Precautions 51. Use waterproof gloves effective radiation shielding and appropriate safety measures when preparing and handling Ga 68 dotatate injection.

Among GEP and UP NETs Dotatate imaging diagnosed primarily new nodal bone liver and pleuralperitoneal metastases missed by other imaging modalities. Results support the routine use of Ga-68 Dotatate PETCT in the care of patients with advanced and early stage NETS.